However, the team also found these toxic gingipains in the brains of deceased patients who were never diagnosed with Alzheimer’s. The question is whether they would have been diagnosed with the disease had they been alive, or whether Alzheimer’s causes poor oral hygiene.
“Our identification of gingipain antigens in the brains of people with AD and also with AD pathology but without a diagnosis of dementia, suggests that brain infection by P. gingivalis is not the result of poor dental hygiene after the onset of dementia or a consequence of the disease in its advanced stage, but rather an early event that may explain the pathology present in middle-aged people before cognitive decline,” the authors explained in their article.
The experiment with mice also revealed a decrease in beta-amyloid production and neuroinflammation due to a component
