Phosphodiesterase inhibitors

The article published in The Anatomical Record describes how popular erectile dysfunction drugs, such as sildenafil (Viagra) and tadalafil (Cialis), have received safety warnings due to cases of sudden hearing loss and vertigo.

The mechanism is not entirely clear, but it is believed to affect blood perfusion in the inner ear, reducing the supply of oxygen and nutrients to the sensory cells.

Although these effects are rare, the increasing popularity of these drugs warrants this warning. Patients who experience ringing in the ears or sudden hearing loss should discontinue use and consult a doctor.

Conclusion

Medications that cause hearing loss present a clinical challenge. Aminoglycosides, cisplatin, loop diuretics, anti-inflammatory drugs, antimalarials, and erectile dysfunction drugs have all been shown to cause deafness, dizziness, and tinnitus.

Scientific knowledge allows for a balanced assessment of risks and benefits, but prevention depends on rigorous medical monitoring. Detecting symptoms early can prevent permanent damage and preserve a healthy quality of life.